2022-23 NFL Opening Season Game: Buffalo Bills vs. Los Angeles Rams September 1, 2022 by Marc Jerbs

On Thursday, September 8, the defending Super Bowl champions Los Angeles Rams will open their season at home against the Buffalo Bills.

Kick-off is set 8:20PM EDT at the SoFi Stadium in Inglewood, CA.

The Buffalo Bills won a total of 11 games last season but was eliminated by the Kansas City Chiefs in the playoffs.

The Bills were heartbroken as they lost in overtime after blowing a late lead.

Buffalo will have QB Josh Allen and WR Stefon Diggs back in their roster.

Their defensive unit will have a further boost with the addition of OLB Von Miller.

The Los Angeles Rams were 12-5 during the regular season and won the Super Bowl LVI.

There are key personnel changes in their roster.

LT Andrew Whitworth retired and they loss CB Darious Williams and OLB Von Miller via free agency.

However, they acquired WR Allen Robinson and LB Bobby Wagner to join the roster with WR Cooper Kupp, DT Aaron Donald and CB Jalen Ramsey.

The sportsbook handicappers have installed the Buffalo Bills as the favorites to win over the Los Angeles Rams on Thursday night's NFL opening season game.