2021-22 NFL Week 1: Indianapolis Colts vs. Seattle Seahawks September 9, 2021 by Marc Jerbs

On Sunday, the Indianapolis Colts will host the Seattle Seahawks in their opening season game at the Lucas Oil Stadium.

Kick-off is set at 1:00PM EDT.

Sunday's game will mark the 13th all-time regular season matchup between both teams.

The Colts leads the series 7-5.

Last time they met was in 2017, wherein the Seahawks defeated the Colts, 46-18.

The Indianapolis Colts went undefeated during the preseason after beating Carolina, Minnesota and Detroit.

Seahawks' coach Pete Carroll is excited to start the season as he wants to see Seattle's retooled offense under new offense coordinator Shane Waldron.

There's a lot of potential for this team this season and they ready to compete against the best in both the AFC and NFC.

The sportsbook handicappers have installed the Indianapolis Colts as the favorites to win over the Seattle Seahawks in Week 1 of the 2021-22 NFL season.